01
ABCDE rule
How to notice a suspicious change.
Read →Knowledge library
Patient resources
Clear explanations of the clinical pathway — from biopsy and pathology to surgery, reconstruction and follow-up.
Expanded
Bone tumours and orthopaedic oncology
Types, specialist pathway, MRI/CT, surgery and functional reconstruction.
New section
Access to treatment
Public programmes, clinical trials, Medevac and real patient routes - with verification dates and official sources.
New format
Patient videos
Short author explanations streamed from YouTube instead of large video files served by the website.
Melanoma
Melanoma
From a suspicious lesion to staging and treatment.
02
After a melanoma diagnosis
First decisions without an unplanned second operation.
Read →03
Breslow thickness
A key measurement in invasive melanoma.
Read →04
Wide local excision
Why it follows diagnostic biopsy.
Read →05
Sentinel lymph node biopsy
From lymphatic mapping to appropriate pathology processing.
Read →SLNB quality
After the sentinel node is removed
Practical tools on mapping, pathology processing and understanding the final report.
After diagnosis
Decisions after a melanoma diagnosis
Focused answers about the next operation, staging, systemic treatment and surveillance.
Why is another operation needed?Why clear biopsy margins do not always complete melanoma surgeryWhen is SLNB discussed?Breslow thickness, risk factors and the role of stagingImmunotherapy and systemic treatmentWhen adjuvant, neoadjuvant or treatment for active disease may be discussedFollow-up after melanoma treatmentSkin and lymph-node review, imaging when appropriate and self-checks
Skin cancer and reconstruction
Skin cancer and reconstruction
BCC, SCC, margin control and defect closure.
01
Basal cell carcinoma
Signs, biopsy and treatment of BCC.
Read →02
Squamous cell carcinoma
Risk factors and treatment principles for SCC.
Read →03
Mohs surgery
Staged micrographic margin control.
Read →04
Reconstruction
Direct closure, flaps and grafts.
Read →05
DFSP
Diagnosis, resection margins and Keystone reconstruction.
Read →Skin Cancer Center 2026
Skin tumours - expanded pathway
From a suspicious lesion and biopsy through BCC/cSCC, rare tumours, Mohs, reconstruction and follow-up.
Skin Cancer CenterPathways + author videos, clinical images and reconstructionPatient guidesBiopsy · postoperative care · follow-up · UV protectionFor cliniciansBCC/cSCC risk · imaging · PNI · nodes · Mohs · immunotherapyActinic keratosis and Bowen diseaseField cancerization · carcinoma in situ · biopsy triggersMerkel cell carcinomaBiopsy · SLNB · RT · immunotherapyRare skin cancersSebaceous · EMPD · angiosarcoma · adnexal · DFSPSebaceous carcinomaEyelid · margin control · Muir-Torre/LynchExtramammary Paget diseasePrimary vs secondary · internal screening · HER2Adnexal carcinomasPorocarcinoma · microcystic adnexal carcinomaCutaneous angiosarcomaBiopsy · local control · RT · systemic treatment
Sarcoma and bone tumours
Sarcoma and bone tumours
The right diagnostic and treatment sequence before the first intervention.
Sarcoma Patient Center 2026
Soft-tissue sarcoma - the full patient pathway
From first suspicion and planned biopsy to subtype, surgery, radiotherapy, systemic treatment, metastatic disease and follow-up.
Sarcoma patient centerStart with your clinical situation - eight patient pathwaysSarcoma for cliniciansAJCC 8 · biopsy · FNCLCC · molecular pathology · RT · systemic treatment
MRI before biopsyWhy the sequence MRI → plan → core biopsy matters
Tumour already removed without a planRestaging, bed MRI, pathology review and planned re-excision
What a pathology report should containSubtype · FNCLCC · mitoses · necrosis · R0/R1/R2 · margins
Molecular diagnosticsMDM2 · SS18::SSX · INI1 · NTRK · FISH · NGS
Sarcoma subtypesLiposarcoma · leiomyosarcoma · synovial · UPS · MFS · epithelioid
RadiotherapyBefore or after surgery - local control, wound healing and late function
Systemic treatmentChemotherapy, subtype-adapted drugs, targeted and cell therapies
Lung metastasesMetastasectomy · SBRT · ablation · systemic treatment
Follow-up after treatmentChest imaging · local MRI · late recurrence · rehabilitation
Is amputation always needed?When limb salvage is feasible and when amputation may still be discussed
Desmoid fibromatosisActive surveillance, DeFi/nirogacestat and when treatment is needed
Wave 1
New bilingual clinical resources
Case-based guidance across sarcoma, skin cancer and melanoma.
MRI before biopsyPlan imaging and tissue diagnosisUnplanned sarcoma excisionWhat happens nextRecurrent sarcomaRestaging and treatment planningPathology reviewResolving diagnostic uncertaintyLimb-sparing surgeryOncologic resection and reconstructionDesmoid fibromatosisWhen surveillance is appropriateBCC of the noseMohs surgery and a bilobed flapAcral melanoma of the footExcision, grafting and wound care
Uveal melanoma
New knowledge cluster
From local control to surveillance, HLA and metastatic treatment.
Uveal melanoma · new resource
Symptoms and diagnosis
Real clinical images, MRI and a modern diagnostic pathway for patients and clinicians.
Melanoma 2.0
New central pathway
Patient-first information with a separate clinician layer. Cutaneous, acral, mucosal and uveal melanoma in one architecture.