Biology
Uveal melanoma is not cutaneous melanoma
Sharing the word melanoma does not make these diseases therapeutically equivalent. Uveal melanoma has different drivers, immune biology and strong hepatic tropism.
For patients and clinicians
Key differences
GNAQ / GNA11Typical early drivers in UM.
Prognostic biologyBAP1, SF3B1, EIF1AX, 15-GEP and PRAME refine risk.
Hepatic tropismThe liver often becomes central to surveillance and metastatic decisions.
For clinicians
Risk stratification and treatment-defining biomarkers are different clinical tasks. A prognostic test should not be interpreted automatically as predictive.