Locoregional treatment
Liver-directed treatment in metastatic uveal melanoma
When hepatic burden drives prognosis and symptoms, liver-directed approaches may become part of the overall plan.
For patients and clinicians
Different methods, different tasks
PHP / HDS
Regional melphalan delivery with extracorporeal filtration in an experienced centre.
Resection / ablation / SBRT
For technically suitable limited burden in selected patients.
Embolisation approaches
Have distinct evidence profiles.
Sequencing: systemic and liver-directed approaches can be complementary; a universal sequence has not been established.