These are educational scenarios without identifying patient data. They are not universal treatment instructions for an individual patient.
01Melanoma and chronic lymphocytic leukaemia
Lymphadenopathy in a person with two malignancies requires confirmation of its origin. Assuming melanoma metastasis without appropriate evidence may lead to incorrect staging.
Tumour board question: What is the actual cause of the lymph node involvement?
02Early recurrence after anti-PD-1
Recurrence following adjuvant immunotherapy calls for renewed staging, a review of previous treatment and relevant molecular information before the next management decision.
Tumour board question: Which findings are needed before choosing local versus systemic treatment?
03Skeletal-muscle involvement
The anatomical relationship to the primary melanoma matters when distinguishing regional spread, in-transit disease and distant metastasis.
Tumour board question: How would correct classification change staging and the role of surgery?
04Oligoprogression during immunotherapy
Progression in a limited number of sites while other disease remains controlled requires individual assessment of local treatment options and whether to change systemic therapy.
Tumour board question: Could local control fit into the overall treatment strategy?